Neuropathological Classification of Huntingtonʼs Disease
نویسندگان
چکیده
منابع مشابه
Neuropathological classification of Huntington's disease.
In postmortem brain specimens from 163 clinically diagnosed cases of Huntington's disease (HD) the striatum exhibited marked variation in the severity of neuropathological involvement. A system for grading this severity was established by macroscopic and microscopic criteria, resulting in five grades (0-4) designated in ascending order of severity. The grade correlates closely with the extent o...
متن کاملNeuropathological alterations in Alzheimer disease.
The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. Despite their inherently cross-sectional nature, postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies...
متن کاملQuantitative neuropathological changes in presymptomatic Huntington's disease.
Morphometric studies of the tail of the caudate nucleus, the site where the pathology is first seen, were performed on 16 brain specimens collected from individuals at risk for inheriting Huntington's disease (HD). Medical records and information obtained from immediate family members indicated that all had died without symptoms of HD. Six individuals had 37 or more CAG repeats and were designa...
متن کاملGlobal democratic consensus on neuropathological disease criteria.
a group of experts in Parkinson's disease attended a satellite meeting of the 7th European Congress of Neuropathology in London, UK, and agreed on a core definition of the histopathological phenotype of Parkinson's disease, which takes into account recent developments in the field (eg, ␣-synuclein immunohistochemistry) but essentially abandons many conventional criteria as they are no longer su...
متن کاملNeuropathological asymmetry in argyrophilic grain disease.
The presence of argyrophilic grains in the neuropil is associated with a form of dementia. We investigated morphological asymmetry in 653 consecutive autopsy patients from a general geriatric hospital (age [mean +/- SD] = 81.1 +/- 8.9 years), focusing on those from patients with advanced argyrophilic grain disease. Paraffin sections of the bilateral posterior hippocampi were immunostained with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1985
ISSN: 0022-3069
DOI: 10.1097/00005072-198511000-00003